Amine Synthesis Reactions - 3.5 Hours (Patreon)

This organic chemistry video tutorial on amine synthesis reactions covers a variety of topics and includes plenty of examples and practice problems to work on.

Here is a list of topics contained in this video:

1. Nomenclature of Amines - IUPAC & Common Names such as Ethanamine & Ethyl Amine

2. Aromatic Heterocycles - Pyrrole, Pyrrolidine, Pyridine, Piperidine, Pyrimidine, Imidazole, & Purine

3. Physical Properties of Amines - Boiling Point, Water Solubility, Polarity, Hydrogen Bonding

4. Basicity of Amines in Gas Phase & Aqueous Phase

5. Acidity of Amine Conjugate Acid - PKa - Electron Donating / Releasing & Withdrawing Groups

6. Quarternary Ammonium Salts - Phase Transfer Catalysts

7. Synthesis of Amines From Alkyl Halides Using NaCN, NaN3, NH3, and NaNH3 Reaction Mechanism

8. Reduction of Nitriles to Amines Using H2 With Pd, Pt, or Ni Catalyst

9. Reduction of Azides Using LiAlH4 Followed By H2O

10. Gabriel Synthesis Reactions of Primary Amines From Alkyl Halides Using H2N-NH2 or N2H4

11. Synthesis of Amino Acids From Alpha Brominated Carboxylic Acids

12. Hoffman Elimination Reaction - Amines to Alkenes Using Excess CH3I, Ag2O, H2O and Heat

13. Oxidation of Tertiary Amines to Amine Oxides Followed By Cope Elimination

14. Anti vs Syn Elimination Stereochemistry - Cope vs Hoffman - Anti-Zaitsev Regiochemistry

15. Hoffman Rearrangement of Amides to Amines Using Br2 / Cl2, OH-, and H2O

16. Curtius Rearrangement of Acid Chlorides to Amines Using NaN3, H2O, and Heat

17. Formation of Alkynes From Alkyl Halides Using NaNH2

18. Ketones to Imines & Enamines

19. Reductive Amination of Ketones Into Primary & Secondary Amines Using NaBH3CN - Sodium CyanoBorohydride

20. Conjugate Addition of Ketones & Amines

21. Formation of Oximes From Ketones Using Hydroxyl Amine - H2N-OH

22. Electrophilic Aromatic Substitution Reactions of Pyrrole at C-2 Position

23. EAS Reactions of Aromatic Heterocycles Such as Furan and Thiophene

24. Nucleophilic Aromatic Reactions of Pyridine Using NaNH2, NaOH, NaSH, CH3MgBr, and NaOCH3

25. Diazotization of Amines Using NaNO2 and HCl or HNO2 / HONO

26. Benzene to Aniline Reactions

27. Sandmeyer Reaction - CuBr, CuCl, CuCN, H3PO2, H3O+, and HBF4

28. Arenediazonium Salts and Diazocoupling

29. Formation of N-nitrosoamines from Secondary Amines

30. Synthesis Reactions - Alkane to Amine

31. Amines From Amides, Ketones, Azides, Alkyl Halides, Alcohols, Etc.

32. Side Chain Reactions of Aromatic Hetereocycles.

33. Proposed Synthesis of Piperazine From Ethane

34. Pyrrolidine to Pentane Reaction Mechanism