Carbonyl Compounds - 5 Hour Video (Patreon)
Content
1. Acid and Base Catalyzed Keto Enol Tautomerization
2. PKa of Carbonyl Compounds - Aldehyde, Ketone, Ester, Amide
3. Carbanion & Enolate Resonance Structures - Major Resonance Contributor
4. Enol Stability - Conjugation, Aromaticity, & Intramolecular Hydrogen Bonding
5. Direct Alkylation of Aldehydes & Ketones Using LDA and an Alkyl Halide - CH3Br
6. Alpha Substitution Reactions - Bromination & HVZ Reaction - Hell Volhard Zelinsky Reaction
7. Base Catalyzed Alpha Hydrogen Substitution - Haloform Reaction For Methyl Ketones - I2 & NaOH or OH-
8. Direct 1,2 Addition vs 1,4 Conjugate Addition - Gilman vs Grignard Reagent
9. Alpha and Beta Hydrogen Substitution With Electrophiles & Nucleophiles
10. Stork Enamine Reaction - Alkylation & Acylation
10. Aldol Addition Reaction Using Acetaldehyde & NaOH
11. Aldol Condensation Reaction Followed By Dehydration Using the E1CB Elimination Reaction
12. Crossed & Mixed Aldol Reaction Plus RetroAldol Reaction Mechanism
13. Cyclic Intramolecular Aldol Reaction
14. Claisen Ester Condensation & Intramolecular Dieckmann Reaction - Appropriate Choice of Base - NaOEt vs NaOH vs NaOMe
15. Malonic Ester Synthesis Reaction - Direct Alkylation, Acid Catalyzed Hydrolysis & Decarboxylation - Alpha Substituted Carboxylic Acids
17. Acetoacetic Ester Synthesis Reaction - Alpha Substituted Ketones
18. Michael Reaction Mechanism - Donor vs Acceptor - Formation of 1,5 Dicarbonyl Compounds
19. Robinson Annulation Reaction Mechanism - Formation of Cyclic 6 membered Rings & alpha beta unsaturated ketones