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Topics Include:

1. Acid and Base Catalyzed Keto Enol Tautomerization 

2. PKa of Carbonyl Compounds - Aldehyde, Ketone, Ester, Amide

3. Carbanion & Enolate Resonance Structures - Major Resonance Contributor

4.  Enol Stability - Conjugation, Aromaticity, & Intramolecular Hydrogen Bonding

5.  Direct Alkylation of Aldehydes & Ketones Using LDA and an Alkyl Halide - CH3Br

6.  Alpha Substitution Reactions - Bromination & HVZ Reaction - Hell Volhard Zelinsky Reaction

7.  Base Catalyzed Alpha Hydrogen Substitution - Haloform Reaction For Methyl Ketones - I2 & NaOH or OH-

8.  Direct 1,2 Addition vs 1,4 Conjugate Addition - Gilman vs Grignard Reagent

9.  Alpha and Beta Hydrogen Substitution With Electrophiles & Nucleophiles

10. Stork Enamine Reaction - Alkylation & Acylation

10.  Aldol Addition Reaction Using Acetaldehyde & NaOH

11.  Aldol Condensation Reaction Followed By Dehydration Using the E1CB Elimination Reaction

12.  Crossed & Mixed Aldol Reaction Plus RetroAldol Reaction Mechanism

13.  Cyclic Intramolecular Aldol Reaction

14.  Claisen Ester Condensation & Intramolecular Dieckmann Reaction - Appropriate Choice of Base - NaOEt vs NaOH vs NaOMe

15.  Malonic Ester Synthesis Reaction - Direct Alkylation, Acid Catalyzed Hydrolysis & Decarboxylation - Alpha Substituted Carboxylic Acids

17.  Acetoacetic Ester Synthesis Reaction - Alpha Substituted Ketones

18.  Michael Reaction Mechanism - Donor vs Acceptor - Formation of 1,5 Dicarbonyl Compounds

19.  Robinson Annulation Reaction Mechanism - Formation of Cyclic 6 membered Rings & alpha beta unsaturated ketones

Files

Carbonyl Compound Reactions -

Carbonyl Compound Reactions

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