Puzzle Gif: GIRLY GAME-IFYING (Patreon)

I think I'm going to occasionally post little puzzles like this on Sundays, fun but perplexing gifs where I let my patrons offer their takes on what the heck is going on. What's the story of this scene? Why did this guy get turned into a girl and sucked into a video game? What is the game, and will he ever escape? I have my ideas, but I'd really like to hear yours!