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Trans-cinnamic acid (Patreon)

Published:
2016-09-28 17:10:36
Edited:
2020-09-04 21:23:15
Imported:
2021-06

Content

Hey guys, just getting the last few out! Ill try to get the IR one done and posted by tomorrow

Files

Making Cinnamic Acid

Today we make some Trans-cinnamic acid from benzaldehyde and malonic acid. The reaction is called the Verley-Doebner modification of the Knoevenagel Condensation. The classic Knoevenagel Condensation is similar to the Aldol Condensation Prep that I followed: http://www.chemistry.mcmaster.ca/~chem3d3/expt5-7.pdf.gz Nile talks about lab safety: https://youtu.be/ftACSEJ6DZA -------------------------------- Patreon: https://www.patreon.com/nilered Youtube Membership: https://www.youtube.com/c/nilered/join NileRed Merch Store (NileRed Pin & Keychain): https://store.dftba.com/collections/nilered NileRed Website (Glassware & Beaker Mugs): https://nile.red -------------------------------- Instagram: https://www.instagram.com/nile.red Twitter: https://twitter.com/NileRed2 Discord: https://discord.gg/3BT6UHf

Comments

Anonymous

Q. could the contaminant be a water or calcium? Would a vacuum oven remove more of the water before storage?

nilered
>>2645898

It definitely wouldn't hurt to pull a vacuum on it. I think an overnight vacuum desiccator would take away almost all of the water. I am honestly not 100% sure what the contaminant is. I got a melting point of 121 and the theoretical is apparently 131ish (i think). So that means the contamination is pretty significant. After a recrystalization, it is odd that is is so contaminated.

Anonymous

Re: patreon rewards: how about something like this (<a href="http://www.shapeways.com/product/QMCYD8664/caffeine?optionId=58282411)" rel="nofollow noopener" target="_blank">http://www.shapeways.com/product/QMCYD8664/caffeine?optionId=58282411)</a> for each video? I.e. for this video, you'd receive a 3D printed model of trans-cinnamic acid

nilered
>>2651808

That would be cool if I were able to do it for cheap. I was thinking more digital rewards though. That is easier to manage and deliver

Anonymous

You mentioned in this video that you were interested in hearing ideas for Patron rewards. I suggest taking requests for what people would like to see synthesized. Here's something to get you started: <a href="http://www.journal.unair.ac.id/filerPDF/06%2009030%20BambangPE%20_format%20FMI_.pdf" rel="nofollow noopener" target="_blank">http://www.journal.unair.ac.id/filerPDF/06%2009030%20BambangPE%20_format%20FMI_.pdf</a>

nilered
>>2874648

That looks pretty cool! Also, the idea of having Patrons vote for which video is posted next and filmed is a pretty good idea.

nilered
>>2874648

For that paper, is there more detail on their procedure besides the flow chart?

Anonymous
>>2874648

As I understand it, what they are describing is the isolation of the newly discovered compound from the Gendarusa plant. Or rather describing the chemical makeup of both compounds Gendarusin A and Gendarusin B that were successfully isolated from the plant. Basically the plant is known to work in Indonesia, the villagers have used it for possibly a hundred years or more. The next step is to try to find a way to synthesize these compounds, in a search for what I have come to understand pharmaceutical companies refer to as a lead compound.

Anonymous
>>2651808

For the idea above, there are 3D printing hubs that will handle the printing and distribution in an automated way. The trick to making it practical would be to have some chemical modeling software, (perhaps quite fun and useful in it's own right), which is capable of punting out an STL file.