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It seems the psychedelic related breakthroughs just keep coming.  CB Therapeutics is the latest to file a new patent that could lead to very efficient production of psilocybin and similar analogs which will help lower costs if psilocybin is ever approved by the FDA as medicine.   That said, the real barrier as far as costs go will likely be the fact that all initial protocols for psilocybin treatment will require many hours of intensive supervision, preparation, and followup/integration time from a licensed/trained professional (psychiatrists or otherwise) - something that could prove cost prohibitive.  It will be interesting to see what solutions develop to address that challenge.  I wonder if there will ever be remote trip sitters or app assisted therapy and integration?  My guess is that the underground self service model will grow after the FDA approves psilocybin for prescriptive use.

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CB Therapeutics Achieves Major Breakthrough in the Biosynthesis of Psilocybin, Psilocin and Related Tryptamine-based Compounds

SAN DIEGO--()--CB Therapeutics, Inc. has achieved the successful biosynthesis of psilocybin, psilocin and related tryptamine-based compounds typically found in plants and fungi and has filed a patent for the production process. In early testing, the analysis of raw analytical samples has shown the biosynthetic process to be significantly more efficient, of higher purity and less expensive than existing chemical and biosynthetic techniques or other production methods.

Comments

Joel Rosenblum

IANAL but how can they patent something that was discovered a few years ago in academia? https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201705489

David Butler

Can anyone link some references to the underground self service mentioned?

GordoTEK

By "underground self service model" I basically mean just people treating themselves without a prescription or the help of a therapist or professional trip sitter. For example by following a modified Griffiths protocol on one's own: https://www.patreon.com/posts/28680845 There is also an existing underground psychedelic therapy network where you can see someone who does this type of work professionally, these practitioners have been interviewed by James Jesso and mentioned by Michael Pollan in his book "How to Change Your Mind": https://amzn.to/2NCiR3N

GordoTEK

I'm not a lawyer either, and only time will tell if this patent is granted, but just because their process was inspired by some academic paper doesn't mean it isn't patentable. They may have come up with a much more elaborate process specifically intended for mass production which hasn't been granted any prior patents. But you have a good point, I'd be surprised if there were not already some patents existing for at least some aspects of the enzymatic production of tryptamines.